SYNTHESIS, BIOLOGICAL-ACTIVITY AND CONFORMATIONAL STUDIES OF GEOMETRICALLY RESTRICTED TRIPEPTIDE ANALOGS OF THE CHEMOATTRACTANT HCO-MET-LEU-PHE-OME

Authors
BOGGIAN M VERTUANI G CAVICCHIONI G PECORARO R SCATTURIN A
Citation
M. Boggian et al., SYNTHESIS, BIOLOGICAL-ACTIVITY AND CONFORMATIONAL STUDIES OF GEOMETRICALLY RESTRICTED TRIPEPTIDE ANALOGS OF THE CHEMOATTRACTANT HCO-MET-LEU-PHE-OME, Il Farmaco, 52(6-7), 1997, pp. 439-444
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
6-7
Year of publication
1997
Pages
439 - 444
Database
ISI
SICI code
0014-827X(1997)52:6-7<439:SBACSO>2.0.ZU;2-S
Abstract
The formyl tripeptides containing 2-azetidinecarboxylic acid 2, 2-pipe ridinecarboxylic acid 3 and norvaline 4 in position 2 were synthesized and their biological activity was evaluated. The conformation of pept ides was studied by CD and FT-IR techniques. While 2 and 3 do not show either chemotactic activity or superoxide production, 4 retains both activities.