MAGNETIC-RESONANCE SPECTROSCOPY OF ISOFLURANE KINETICS IN HUMANS .1. ELIMINATION FROM THE HEAD

Authors
LOCKWOOD GG DOB DP BRYANT DJ WILSON JA SARGENTONI J SAPSEDBYRNE SM HARRIS DNF MENON DK
Citation
Gg. Lockwood et al., MAGNETIC-RESONANCE SPECTROSCOPY OF ISOFLURANE KINETICS IN HUMANS .1. ELIMINATION FROM THE HEAD, British Journal of Anaesthesia, 79(5), 1997, pp. 581-585
Citations number
22
Categorie Soggetti
Anesthesiology
Journal title
British Journal of Anaesthesia → ACNP
ISSN journal
00070912
Volume
79
Issue
5
Year of publication
1997
Pages
581 - 585
Database
ISI
SICI code
0007-0912(1997)79:5<581:MSOIKI>2.0.ZU;2-J
Abstract
We describe the first human experiments to demonstrate wash-out of iso flurane using fluorine magnetic resonance spectroscopy. Using a surfac e receive coil, we found two-compartment kinetics within the head with decay half-times of 9.5 and 130 min, but the signal was too weak to l ocalize the compartments. If the fast compartment is assumed to be the brain then our results match the predictions of the classical perfusi on-limited pharmacokinetic model of inhalation anaesthesia.