COMPARISON OF PERIOPERATIVE KETOPROFEN 2.0 MG KG(-1) WITH 0.5 MG KG(-1) IV IN SMALL CHILDREN DURING ADENOIDECTOMY

We have investigated if ketoprofen 0.5 mg kg(-1) i.v. provided as good analgesia with less adverse effects compared with ketoprofen 2.0 mg k g(-1) i.v. in 107 children, aged 1-7 yr, after adenoidectomy, in a ran domized, double-blind, parallel group study design. PI standard anaest hetic method was used and all children received fentanyl 1 mu g kg(-1) i.v. during induction. Children in group 2.0 received ketoprofen 2.0 mg kg(-1) and children in group 0.5, 0.5 mg kg(-1) i.v, during inducti on. if the child was in pain, fentanyl 1 mu g kg(-1) was given i.v. as rescue analgesia. We found that ketoprofen provided good analgesia an d only 49% of children required fentanyl in the post-anaesthesia care unit. There were no differences between the groups in the number of fe ntanyl doses, pain scores or frequency of adverse reactions. No seriou s adverse reactions occurred.