NEURULATION - COMING TO CLOSURE

Neurulation is a morphogenetic event pas excellence, During this highl y choreographed four-dimensional process, a flat sheet of ectoderm is transformed into an elongated tubular rudiment, the neural tube, which exhibits rostro-caudal and mediolateral regionalization. Many tissues interact during neurulation to induce and regionalize the neuroectode rm and to produce the morphogenetic forces that drive neurulation, Suc h forces are generated by fundamental cell behaviors such as changes i n cell shape, position and number. In addition, morphoregulatory molec ules expressed during neurulation underlie induction and patterning of the forming neuraxis. Despite recent advances in our understanding of neurulation, neural tube defects continue to be a major health care c oncern, Further research, utilizing a panoply of approaches, is necess ary to resolve this issue. Thus, although we are beginning to come to closure in terms of understanding the cellular and molecular mechanism s responsible for normal neural tube formation, 'coming to closure' is exactly the problem that requires resolution to prevent these devasta ting birth defects.