PEPTIDE-INDUCED DELETION OF CD8 T-CELLS IN-VIVO OCCURS VIA APOPTOSIS IN-SITU

Citation
C. Koniaras et al., PEPTIDE-INDUCED DELETION OF CD8 T-CELLS IN-VIVO OCCURS VIA APOPTOSIS IN-SITU, International immunology, 9(10), 1997, pp. 1601-1605
Citations number
23
Categorie Soggetti
Immunology
Journal title
ISSN journal
09538178
Volume
9
Issue
10
Year of publication
1997
Pages
1601 - 1605
Database
ISI
SICI code
0953-8178(1997)9:10<1601:PDOCTI>2.0.ZU;2-J
Abstract
The ultimate fate of T cells undergoing antigen-induced cell death in vivo remains controversial. Whereas apoptosis of CD4(+) T cells driven by superantigen is readily detectable in lymphoid organs, CD8(+) T ce lls have been reported to disappear from the lymphoid organs and accum ulate in the liver where they undergo apoptosis, Using transgenic mice that produce large numbers of ovalbumin-specific CD8(+) T cells (OT-I cells), we were able to investigate the events that follow soluble pe ptide administration in an independent CD8(+) T cell system, Here we s how that the OT-I cells undergo proliferation and apoptosis in situ in lymphoid organs in response to antigenic stimulation with no evidence for liver involvement. This is similar to the course of events found for CD4(+) T cell activation and counters the view that the liver is a general site for CD8(+) T cell clearance following antigen-specific a ctivation.