DISPOSITION OF FUSIDIC ACID DURING PERITONEAL-DIALYSIS

Fusidic acid has characteristics that suggest it might be a useful age nt in the management of staphylococcal peritonitis in patients undergo ing peritoneal dialysis. The present investigation was undertaken to e stablish the relationship between serum and peritoneal dialysis efflue nt concentrations of fusidic acid and to determine whether therapeutic levels of fusidic acid could be achieved in the dialysate following o ral administration of the agent. Concentrations of fusidic acid up to 80 times the MIC for staphylococci were found after repeated oral dose s. The results have provided basic data needed to initiate clinical st udies of the role of fusidic acid as an adjunctive agent in the manage ment of staphylococcal peritonitis.