A SPLICE VARIANT OF DP71 LACKING THE SYNTROPHIN BINDING-SITE IS EXPRESSED IN EARLY STAGES OF HUMAN NEURAL DEVELOPMENT

Citation
M. Ceccarini et al., A SPLICE VARIANT OF DP71 LACKING THE SYNTROPHIN BINDING-SITE IS EXPRESSED IN EARLY STAGES OF HUMAN NEURAL DEVELOPMENT, Developmental brain research, 103(1), 1997, pp. 77-82
Citations number
51
Categorie Soggetti
Neurosciences
ISSN journal
01653806
Volume
103
Issue
1
Year of publication
1997
Pages
77 - 82
Database
ISI
SICI code
0165-3806(1997)103:1<77:ASVODL>2.0.ZU;2-A
Abstract
Dp71, a 71 kDa C-terminal isoform of dystrophin, is the major product of the DMD gene in brain. Two alternatively spliced transcripts of Dp7 1 were amplified by RT-PCR from different areas of human fetal neural tissue. Both transcripts were spliced out of exons 71 and 78. The shor ter transcript was also alternatively spliced of exons 72-74, a region comprising the coding sequence for the binding site to syntrophin, on e component of the dystrophin-associated protein complex. Results indi cate that alternatively spliced forms of Dp71 are regulated during hum an neural development. (C) 1997 Elsevier Science B.V.