ADRENAL-STEROIDS SUPPRESS GRANULE CELL-DEATH IN THE DEVELOPING DENTATE GYRUS THROUGH AN NMDA RECEPTOR-DEPENDENT MECHANISM

Authors
GOULD E TANAPAT P CAMERON HA
Citation
E. Gould et al., ADRENAL-STEROIDS SUPPRESS GRANULE CELL-DEATH IN THE DEVELOPING DENTATE GYRUS THROUGH AN NMDA RECEPTOR-DEPENDENT MECHANISM, Developmental brain research, 103(1), 1997, pp. 91-93
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Developmental brain research → ACNP
ISSN journal
01653806
Volume
103
Issue
1
Year of publication
1997
Pages
91 - 93
Database
ISI
SICI code
0165-3806(1997)103:1<91:ASGCIT>2.0.ZU;2-W
Abstract
Treatment with the NMDA receptor antagonist MK-801 prevented the adren al steroid-induced suppression of cell death, determined by both morph ological identification of pyknotic cells and TUNEL staining, in the d entate gyrus in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation. (C) 1997 Elsevier Science B.V.