PROLYL ENDOPEPTIDASE INHIBITORS DERIVED FROM ACTINOMYCETES

Four prolyl endopeptidase inhibitors isolated from actinomycetes, name d propeptin, SNA-8073-B, staurosporine, and enduracidin were classifie d into 3 groups on the basis of their inhibition potency against proly l endopeptidase from a bacterium (Flavobacterium) and a mammal (human placenta). Staurosporine inhibited the enzyme from Flavobacterium more strongly than that from human placenta. Enduracidin inhibited the enz yme from human placenta more strongly than that from Flavobacterium. P ropeptin and SNA-8073-B, both new compounds, inhibited the enzymes fro m both origins to the same extent.