PURPOSE: To describe and evaluate a method of tomosynthesis breast ima
ging with a full-field digital mammographic system. MATERIALS AND METH
ODS: In this tomosynthesis method, low-radiation-dose images were acqu
ired as the x-ray source was moved in an are above the stationary brea
st and digital detector. A step-and-expose method of imaging was used.
Breast tomosynthesis and conventional images of two imaging phantoms
and four mastectomy specimens were obtained. Three experienced readers
scored the relative lesion visibility, lesion margin visibility, and
confidence in the classification of six lesions. RESULTS: Tomosynthesi
s image-reconstruction algorithms allow tomographic imaging of the ent
ire breast from a single are of the x-ray source and at a radiation do
se comparable with that in single-view mammography. Except for images
of a large mass in a fatty breast, the tomosynthesis images were super
ior to the conventional images. CONCLUSION: Digital mammographic syste
ms make breast tomosynthesis possible. Tomosynthesis may improve the s
pecificity of mammography with improved lesion margin visibility and m
ay improve early breast cancer detection, especially in women with rad
iographically dense breasts.