HIV-ASSOCIATED HUMAN-HERPESVIRUS 8-POSITIVE PRIMARY LYMPHOMATOUS RADIOLOGIC FINDINGS IN 6 PATIENTS

PURPOSE: To define the imaging features of body cavity-based lymphoma (BCBL) related to the acquired immunodeficiency syndrome. This is a pe culiar type of non-Hodgkin lymphoma harboring infection by human herpe svirus 8 (HHV-8) and displaying a peculiar tropism for the serous body cavities. MATERIALS AND METHODS: At diagnosis of BCBL, six consecutiv e patients were investigated with radiography of the chest and convent ional computed tomography (CT) of the chest and abdomen. For all patie nts, clinical features and results of biologic characterization of the lymphoma were also available, RESULTS: In all patients, chest radiogr aphs displayed bilateral or unilateral pleural effusion in the absence of parenchymal opacities or mediastinal enlargement. CT scans confirm ed chest radiographic findings and revealed a slight thickening of the parietal pleura in all patients and a pericardial thickening in four patients. CT also depicted pericardial and abdominal effusions in five and two patients, respectively, in the absence of solid tumor masses or parenchymal abnormalities. CONCLUSION: BCBL must be included among the differential diagnoses of serous effusions detected radiologically in individuals infected with the human immunodeficiency virus (HIV). Since the combination of serous effusion, slight serosal thickening, a nd absence of solid masses is compatible with, though not specific for , BCBL in the context of HIV infection, radiologic findings need to be complemented by a detailed biologic and virologic characterization of tumor cells.