PURPOSE: To evaluate the appearance of the sciatic nerve after leg amp
utation.MATERIALS AND METHODS: Magnetic resonance (MR) images were obt
ained in seven patients (age at amputation, 11-19 years) who underwent
above-knee amputation to treat osteogenic sarcoma. Images were evalua
ted for sciatic nerve enlargement. Findings were correlated with the t
ime after amputation. RESULTS: All seven patients were found to have a
markedly enlarged sciatic nerve in the stump of the amputated leg. Th
e enlargement extended proximally from the point of nerve transection
to a level posterior to the femoral neck (8-27 cm) depending on the le
ngth of the stump. No evidence of sciatic nerve enlargement was found
in the opposite leg or on preoperative MR images that were available i
n three of the patients. Moreover, in one patient with a sarcoma who u
nderwent a leg-sparing procedure, no sciatic nerve enlargement was see
n postoperatively. The thickness of the distal sciatic nerve was relat
ed to the time after amputation. CONCLUSION: Hypertrophy of the sciati
c nerve occurred after above-knee amputation in young patients. This f
inding differed from atrophy of the nerve that has been reported previ
ously in older patients.