THE SELECTIVE D-2-DOPAMINE-RECEPTOR ANTAGONIST ETICLOPRIDE COUNTERACTS THE EJACULATIO-PRAECOX INDUCED BY THE SELECTIVE D-2-DOPAMINE AGONISTSND-919 IN THE RAT

The selective D-2 antagonist eticlopride, at a dose (0.01 mg/kg, s.c.) that fails to modify the normal behavior of rats, significantly rever sed all the behavioral effects exerted by the selective D-2 agonist SN D 919 (0.1 mg/kg, i.p.), namely, the stimulation of stretching-yawning , penile erection and sedation and the inhibition of grooming. In the copulatory test, eticlopride at the same dose did not affect animal se xual behavior but potently counteracted the reduction in mount and int romission frequency and latency to ejaculation induced by SND 919 at 0 .1 mg/kg, a behavioral pattern which might possibly be proposed as an animal model for human ejaculatio praecox.