IN-VIVO EFFECTS OF MILLIMETER WAVES ON CELLULAR-IMMUNITY OF CYCLOPHOSPHAMIDE-TREATED MICE

Reactions of peritoneal macrophages (PM) and T lymphocytes of BALB/c m ice to in vivo exposure to millimeter (MM) waves were studied. The mic e were additionally treated with the antineoplastic drug cyclophospham ide (CPA) 100 mg/kg. Phagocytosis of Candida albicans cells by PM obta ined from mice treated with CPA and MM waves, alone and in combination , was studied in vitro using a monolayer technique. Proliferation of m urine T cells (splenocytes) was studied by H-3-thymidine incorporation into DNA of T lymphocytes without stimulation and after stimulation w ith anti-CD3 antibody 2C11. The results of this study show that 61.22 GHz MM waves with an incident power density of 15 mW/cm(2) and a peak SAR of 420 W/kg significantly reduce the toxic effects of CPA on cellu lar immunity of mice in vivo as observed by the increased PM phagocyti c activity and enhancement of T-cell proliferation.