This paper presents techniques of parameter estimation in heteroskedas
tic mixed models having constant variance ratios and heterogeneous log
residual variances that are described by a linear model. Estimation o
f dispersion parameters is by standard (ML) and residual (REML) maximu
m likelihood. Estimating equations are derived using the expectation-c
onditional maximization (ECM) algorithm and simplified versions of it
(gradient ECM). Direct and indirect approaches are proposed with the l
atter allowing hypothesis testing about the variance ratios. The analy
sis oi a small example is outlined to illustrate the theory.