SEVERE MULTICENTRIC RETICULOHISTIOCYTOSIS - DISEASE STABILIZATION ACHIEVED WITH METHOTREXATE AND HYDROXYCHLOROQUINE

Multicentric reticulohistiocytosis is a rare systemic disease that typ ically manifests as erosive polyarthritis. The particularly aggressive nature of multicentric reticulohistiocytosis has led many to recommen d treatment with high dose corticosteroids, alkylating agents, or both . We describe a 56-year-old woman with erosive polyarthritis successfu lly treated exclusively for 30 months with hydroxychloroquine and meth otrexate, This regimen may have the potential to provide longterm dise ase control with reduced risk of serious drug related toxicity.