We report a case of lupus induced by mesalazine therapy taken for aver
a year for Crohn's disease, The patient had polyarthritis, alopecia,
lymphoneutropenia, antinuclear factors, anti-histone antibodies, anti-
Sm and anti-RNP, Discontinuation of mesalazine was followed by rapid r
esolution of the joint manifestations, alopecia and lymphoneutropenia;
the anti-histone antibodies fell to undetectable levels and the titer
s of the other auto-antibodies decreased gradually.