In order to determine if hantaviruses were present in mice and other s
mall mammals in Indiana (USA), small mammals were trapped in Brown, La
Porte, Tippecanoe and Whitley counties. Sixty-seven small mammals were
trapped during August and September 1994. Sixty-three Peromyscus leuc
opus, one Microtus pennsylvanicus, one Zapus hudsonius and two Blarina
brevicauda were captured and tested for hantaviruses. Six P. leucopus
were found to have antibody to Sin Nombre virus (SN) by IgG ELISA, an
d a 139 bp fragment of SN-like hantavirus was amplified from five of t
hem. All six of the positive P. leucopus were from LaPorte County. No
other small mammals had evidence of infection with SN virus. This stud
y presents the first report of Sin Nombre-like hantavirus in P. leucop
us from Indiana.