CHANGES IN LDH ISOZYME PATTERN IN UTERINE FLUID OF MICE DURING EARLY-PREGNANCY

The total LDH activity in the uterine fluid of mice shows a rising tre nd From the first day after mating (DAM-1) to the seventh day after ma ting (DAM-7). This suggests that LDH activity increases as gestation p rogresses, During early pregnancy, M-isozymes of LDH show a predominan ce from DAM-1 to DAM-3 in the uterine luminal fluid of mice, while H-i sozyme shows a rising level from DAM-5 (implantation day) and attains a maximum level at DAM-7 (the post-implantation period), Such shift of M-isozymes into H-isozymes of LDH (Lactate dehydrogenase) during pre- implantation (DAM-3) to post-implantation (DAM-7) period changes the u terine luminal environment from anaerobic to aerobic condition which i s more conducive for the normal development, implantation and survival of the growing blastocyst.