SYNTHESIS OF NOVEL HETEROCYCLES THROUGH REACTION OF INDOLIN-2-ONE DERIVATIVES WITH ACTIVE METHYLENE AND AMINO REAGENTS

Authors
ABDELLATIF FF AHMED EK MEKHEIMER R MASHALY MM
Citation
Ff. Abdellatif et al., SYNTHESIS OF NOVEL HETEROCYCLES THROUGH REACTION OF INDOLIN-2-ONE DERIVATIVES WITH ACTIVE METHYLENE AND AMINO REAGENTS, Archives of pharmacal research, 20(5), 1997, pp. 507-509
Citations number
9
Categorie Soggetti
Biology
Journal title
Archives of pharmacal research → ACNP
ISSN journal
02536269
Volume
20
Issue
5
Year of publication
1997
Pages
507 - 509
Database
ISI
SICI code
0253-6269(1997)20:5<507:SONHTR>2.0.ZU;2-3
Abstract
Several new spiro compounds were synthesized via one-pot ternary conde nsation of isatin, malononitrile and each of thiobarbituric acid, barb ituric acid, 3-methyl-pyrazolin-5-one, 1-phenyl-3-methyl-pyrazolin-5-o ne, acetylacetone, benzoylacetone, ethyl acetoacetate, phenacyl cyanid e or ethyl-cyanoacetate dimer. Structures and reaction mechanisms were reported and supported via a second synthetic route.