THE FUNGAL BIOSYNTHESIS OF 3-NITROPROPIONIC ACID - IS THE DECARBOXYLATION OF L-NITROSUCCINATE AN ENZYMATIC-REACTION

Authors
BAXTER RL SMITH SL MARTIN JR HANLEY AB
Citation
Rl. Baxter et al., THE FUNGAL BIOSYNTHESIS OF 3-NITROPROPIONIC ACID - IS THE DECARBOXYLATION OF L-NITROSUCCINATE AN ENZYMATIC-REACTION, Journal of the Chemical Society. Perkin transactions. I, (16), 1994, pp. 2297-2299
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
16
Year of publication
1994
Pages
2297 - 2299
Database
ISI
SICI code
0300-922X(1994):16<2297:TFBO3A>2.0.ZU;2-J
Abstract
In vitro enzymatic hydrolysis of diethyl (RS)-nitrosuccinate 2c by pig liver esterase at pH 7.8 affords 3-nitropropionic acid 1 indicating t hat the decarboxylation of (RS)-nitrosuccinate 2b is spontaneous under physiological conditions. In the in vivo synthesis of 1 from L-aspart ate by cells of Penicillium atrovenetum, which involves oxidation of L -aspartate to nitrosuccinic acid, the decarboxylation of the nitrosucc inate may not require a specific biological catalyst.