SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME YL-2-ACYLALKYLIDENE-2,3-DIHYDRO-1,3-BENZOTHIAZOLES

Several N-alkenyl-2-acylalkylidene-2,3-dihydro-1,3- benzothiazoles (4) were synthesized and tested for in vitro antibacterial activity again st different Gram-positive and Gram-negative bacteria. Compounds 4 wer e also tested for antifungal activity against Saccharomyces cerevisiae . The findings clearly showed that all the compounds 4 were devoid of antifungal activity, whereas errs the compounds 4i-m,o-r were effectiv e against the bacterial strains used. Compounds 4k,m,p,q proved to be the most active antibacterial agents showing in some cases minimum inh ibitory concentrations (MIC) lower than chloramphenicol and gentamicin , used as reference compounds. In the case of two representative bacte rial strains (Gram-positive and Gram-negative, respectively), a parabo lic relationship was found between the antibacterial activity of compo unds 4i-m,o-r expressed as log1/MIC and the molecular lipophilicity me asured as R(M) values.