IN-VITRO STUDIES OF THE ANTIBACTERIAL AND ACTIVITY OF OXINE AND ITS DERIVATIVES

Twenty-one derivatives of 8-hydroxyquinoline (oxine, 8H, CAS 148-24-3) were prepared and characterized by UV IR, MS and NMR spectroscopy. Fo ur of these derivatives, N-butyl, 8-butyloxyquinolinium bromide (HBD), 8-pentyloxyquinoline (HPEM), N-pentyl, 8-pentyloxyquinoline bromide ( HPED) and N-benzyl, 8-benzyloxy quinolinium chloride (HBED) are new an d reported for the first time. The antimicrobial activity of these com pounds was carried out in vitro against 11 Gram positive and 18 Gram n egative bacteria, and 18 fungi including 9 dermatophytes, 7 other fila mentous fungi and 2 Candida species. Three compounds namely, HPRD, HPE D and HBED were found to possess significant antibacterial activity in order of HPED > HPRD > HBED, whereas 4 were found to possess signific ant antifungal activity in or order of 8H > HT > HPEM > 8B.