D. Bowlin et al., INFLUENCE OF INTEGRATOR PARAMETERS ON ESTIMATES CALCULATED WITH THE STATISTICAL-MODEL OF OVERLAP, Journal of chromatography, 677(2), 1994, pp. 307-318
The effect of the slope and area thresholds of a digital integrator on
the calculation of component numbers with the statistical model of ov
erlap (SMO) is critiqued. As these thresholds increase, the numbers of
maxima recognized by the integrator and components calculated with th
e SMO both decrease. With modest changes in threshold, the maxima and
component numbers decrease proportionally, such that their ratio remai
ns constant. For larger changes in threshold, the number of components
usually decreases more rapidly than the number of maxima. Computer si
mulations are developed that confirm the general trend of these observ
ations. The implications of these variations are discussed.