We have calculated the isotope effect coefficient and the critical tem
perature in a particular superconducting heterostructure formed by a b
idimensional (2D) superlattice of metallic quantum stripes. We model t
he superlattice with a 2D free electron gas confined in a ID periodic
potential barrier. Within the BCS theory we calculate the shape resona
nce for the critical temperature and the isotope coefficient as a func
tion of the chemical potential. The results provide a good description
of the anomalous behavior of the isotope coefficient in La2-xSrxCuO4
as a function of doping with a sharp peak alpha similar to 0.8 in the
underdoped regime and a rapid drop to alpha similar to 0.2 at 0.125 ho
les per copper site.