CLINICAL-PHARMACOLOGY AND MALARIA

The role of clinical pharmacology in improving the prevention and trea tment of malaria is reviewed. A series of general and specific issues is discussed, concentrating on risk-benefit and cost-effectiveness. Th e techniques of clinical pharmacokinetics play an important role in th e optimal use of drugs and this is illustrated by studies on quinine a nd proguanil. In discussing amodiaquine toxicity, the role of the phar macologist and the chemist in designing out drug toxicity lends hope f or producing a new generation of antimalarial drugs.