ORTHOTOPIC TRANSPLANTATION OF A PARTIAL HEPATIC AUTOGRAFT IN DOGS

The purpose of this study was to investigate the availability of an or thotopic transplantation of partial hepatic autograft in dogs as a mea ns of surgical training. Male mongrel dogs weighting 10-15kg were used , The left lobe of the liver was harvested while preserving the left b ranches of the portal vein, hepatic artery and bile duct, and the left hepatic vein, The remnant liver was removed while preserving the infe rior vena cava using a veno-venous bypass, Orthotopic transplantation of the autograft was performed while anastomosing the left hepatic vei n to the inferior vena cava, portal and arterial reconstruction, and e xternal biliary drainage, Thirteen out of 29 dogs survived more than 4 8h after transplantation, However, 6 out of 13 dogs were sacrificed af ter developing bile peritonitis due to a dislodgement of the biliary c atheter, and only two dogs were able to survive for 7 days after trans plantation, The arterial ketone body ratio recovered to 1.0 within 10 after reperfusion, and the ratio of the dogs that survived for more th an 48h remained above 1.0 until sacrifice, Orthotopic transplantation of a partial hepatic autograft is a useful and simple procedure to tra in surgeons for partial liver transplantation.