A RAT MODEL WITH AN ISOLATED BLADDER IN-SITU

Citation
J. Thulesen et al., A RAT MODEL WITH AN ISOLATED BLADDER IN-SITU, SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 27(11), 1997, pp. 1089-1092
Citations number
8
Categorie Soggetti
Surgery
ISSN journal
09411291
Volume
27
Issue
11
Year of publication
1997
Pages
1089 - 1092
Database
ISI
SICI code
0941-1291(1997)27:11<1089:ARMWAI>2.0.ZU;2-J
Abstract
This paper describes our method for producing a rat model with an isol ated bladder in situ in which the bladder makes no contact with urine. First, the right kidney was removed, then an external catheter was pl aced in the right ureter for bladder infusions, and next the left uret er was anatomosed to the proximal part of the descending colon. The an imals were treated with antibiotics, and saline was infused daily into the bladder in order to prevent atrophy. This in situ model is consid ered to be useful in studies investigating the influence of specific c ompounds, such as carcinogens, on the bladder and ifs urothelium.