A RAT MODEL WITH AN ISOLATED BLADDER IN-SITU

This paper describes our method for producing a rat model with an isol ated bladder in situ in which the bladder makes no contact with urine. First, the right kidney was removed, then an external catheter was pl aced in the right ureter for bladder infusions, and next the left uret er was anatomosed to the proximal part of the descending colon. The an imals were treated with antibiotics, and saline was infused daily into the bladder in order to prevent atrophy. This in situ model is consid ered to be useful in studies investigating the influence of specific c ompounds, such as carcinogens, on the bladder and ifs urothelium.