T-CELL DEFINED TUMOR-ANTIGENS

T cell defined antigens have now been characterized in a large variety of tumor types, in both mice and humans. An increasing number of thes e antigens appear to result from tumor-specific mutations, and some of these mutations may be implicated in oncogenesis. The priority is now to demonstrate that immunization against some of these antigens is cl inically valuable for antitumor therapy, and the first results of clin ical pilot studies are now emerging.