PROSPECTS FOR ADOPTIVE T-CELL THERAPY

Since the establishment of methods to isolate genes encoding cytotoxic T lymphocyte defined tumor antigens, several antigens have been ident ified and characterized for suitability as target antigens for immunot herapy. The development of innovative strategies to generate T cells t argeting these antigens and lessons learned from clinical trials of ad optive immunotherapy of viral diseases should facilitate the design of clinical trials for specific adoptive immunotherapy of cancer.