REDUCED LOA-LOA MICROFILARIA COUNT 10 TO 12 MONTHS AFTER A SINGLE-DOSE OF IVERMECTIN

Authors
DUONG TH KOMBILA M FERRER A BUREAU P GAXOTTE P RICHARDLENOBLE D
Citation
Th. Duong et al., REDUCED LOA-LOA MICROFILARIA COUNT 10 TO 12 MONTHS AFTER A SINGLE-DOSE OF IVERMECTIN, Transactions of the Royal Society of Tropical Medicine and Hygiene, 91(5), 1997, pp. 592-593
Citations number
12
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
Journal title
Transactions of the Royal Society of Tropical Medicine and Hygiene → ACNP
ISSN journal
00359203
Volume
91
Issue
5
Year of publication
1997
Pages
592 - 593
Database
ISI
SICI code
0035-9203(1997)91:5<592:RLMC1T>2.0.ZU;2-O
Abstract
The action of a single dose of ivermectin (200 mu g/kg) on 71 Gabonese patients with Loa loa microfilariae in the peripheral blood, and livi ng in areas highly endemic for loiasis, has been evaluated. Ten to 12 months after treatment, 43 patients (63%) had no circulating microfila ria and the geometric mean peripheral blood microfilaria count had dec reased by 88.6% (P<0.02). Thus, a single annual dose of ivermectin can markedly reduce loiasis transmission.