The statistic data evidence for rapid increase of the number of narcom
anias, especially in juveniles and young people nowadays in Russia. Th
e spectrum of psychoactive preparations used became also wider. On the
basis of medicobiological studies the conception concerning main path
ogenetic machanisms of the development of psychoactive substances depe
ndence was formulated. Enzyme immune assays either for diagnosis of lo
ng-term opiate administration or for determination of blood serum meth
adone level were elaborated. Clinical studies demonstrated pathomorphi
sm of the symptoms of dependence upon well-known narcotics. Clinical p
attern of dependence upon new psychoactive preparations which cause de
pendence syndrome was also investigated. New differentiated methods of
treatment of various types of narcomanias are proposed. There is unde
rlined that a comprehensive program of narcomanias prophylaxis in Russ
ia is needed.