ENANTIOSEPARATIONS BY ELECTROCHROMATOGRAPHY WITH PACKED CAPILLARIES

(S)-Naproxen-derived and (SR,4S)-Whelk-O chiral stationary phases (CSP s) were immobilized on 3 mu m silica supports and packed into 100 mu m I.D. fused-silica capillaries. Enantiomers of some neutral analytes r epresenting a variety of different classes of compounds were separated by electrochromatography using 2-(N-morpholino)ethanesulfonic acid mo dified with acetonitrile as the buffer system. High column efficiency (up to 200 000 plates per meter) and substantial levels of enantiosele ctivity were obtained in all cases with separations usually being perf ormed in less than 10 min. (C) 1997 Elsevier Science B.V.