THE ROLE OF THE CYTOSKELETON IN MIGRATION AND PROLIFERATION OF A CULTURED HUMAN GASTRIC-CANCER CELL-LINE USING A NEW METASTASIS MODEL

Authors
IWAZAKI R WATANABE S OTAKA K OTA K ONO Y SATO N
Citation
R. Iwazaki et al., THE ROLE OF THE CYTOSKELETON IN MIGRATION AND PROLIFERATION OF A CULTURED HUMAN GASTRIC-CANCER CELL-LINE USING A NEW METASTASIS MODEL, Cancer letters, 119(2), 1997, pp. 191-199
Citations number
30
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
119
Issue
2
Year of publication
1997
Pages
191 - 199
Database
ISI
SICI code
0304-3835(1997)119:2<191:TROTCI>2.0.ZU;2-8
Abstract
Using an in vitro model for investigating the mechanism of migration a nd proliferation of a cultured human gastric cancer cell line which we established recently, we studied the suppressive effect of inhibitors of the cytoskeleton proteins, actin and myosin, on the migration and proliferation of cancer cells. These inhibitors suppressed the capacit y of cancer cells to migrate and proliferate dose-dependently. Thus th e integrity of the cytoskeletal system may play an important role in t he mechanism of metastasis of gastric cancer cells. (C) 1997 Elsevier Science Ireland Ltd.