CHARACTERIZATION OF CIPROFLOXACIN LIPOSOMES - DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRIC DETERMINATIONS

Citation
A. Gursoy et B. Senyucel, CHARACTERIZATION OF CIPROFLOXACIN LIPOSOMES - DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRIC DETERMINATIONS, Journal of microencapsulation, 14(6), 1997, pp. 769-776
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Applied","Engineering, Chemical
ISSN journal
02652048
Volume
14
Issue
6
Year of publication
1997
Pages
769 - 776
Database
ISI
SICI code
0265-2048(1997)14:6<769:COCL-D>2.0.ZU;2-6
Abstract
Neutral, (-) and (+) charged CF encapsulated liposome formulations pre pared with EPC:Chol and DPPC:Chol lipids were investigated for their l oading capacity, encapsulation % and release properties. CF amounts in the liposomes were estimated using derivative UV spectroscopy. Among the liposome formulations DPPC:Chol and EPC:Chol neutral formulations had a significantly higher loading capacity and slowest release rate c ompared with (-) and (+) charged liposomes. The derivative UV spectros copy was found to be an easy and sensitive method for direct estimatio n of CF in liposomes.