CHARACTERIZATION OF CIPROFLOXACIN LIPOSOMES - DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRIC DETERMINATIONS

Neutral, (-) and (+) charged CF encapsulated liposome formulations pre pared with EPC:Chol and DPPC:Chol lipids were investigated for their l oading capacity, encapsulation % and release properties. CF amounts in the liposomes were estimated using derivative UV spectroscopy. Among the liposome formulations DPPC:Chol and EPC:Chol neutral formulations had a significantly higher loading capacity and slowest release rate c ompared with (-) and (+) charged liposomes. The derivative UV spectros copy was found to be an easy and sensitive method for direct estimatio n of CF in liposomes.