A. Gursoy et B. Senyucel, CHARACTERIZATION OF CIPROFLOXACIN LIPOSOMES - DERIVATIVE ULTRAVIOLET SPECTROPHOTOMETRIC DETERMINATIONS, Journal of microencapsulation, 14(6), 1997, pp. 769-776
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Applied","Engineering, Chemical
Neutral, (-) and (+) charged CF encapsulated liposome formulations pre
pared with EPC:Chol and DPPC:Chol lipids were investigated for their l
oading capacity, encapsulation % and release properties. CF amounts in
the liposomes were estimated using derivative UV spectroscopy. Among
the liposome formulations DPPC:Chol and EPC:Chol neutral formulations
had a significantly higher loading capacity and slowest release rate c
ompared with (-) and (+) charged liposomes. The derivative UV spectros
copy was found to be an easy and sensitive method for direct estimatio
n of CF in liposomes.