EFFICIENT RESOLUTION OF OXIDIZED CLELANDS REAGENT BY C2-SYMMETRICAL BOC-L-PBENYLALANYL ESTERS

Authors
EVANS CA BERNIER L DUGAS J MANSOUR TS
Citation
Ca. Evans et al., EFFICIENT RESOLUTION OF OXIDIZED CLELANDS REAGENT BY C2-SYMMETRICAL BOC-L-PBENYLALANYL ESTERS, Tetrahedron letters, 38(44), 1997, pp. 7657-7660
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
44
Year of publication
1997
Pages
7657 - 7660
Database
ISI
SICI code
0040-4039(1997)38:44<7657:EROOCR>2.0.ZU;2-C
Abstract
Trans 4,5-dihydroxy-1,2-dithiane (1,oxidized form of Cleland's reagent ; dithiothreitol) is resolved efficiently in > 99% overall e.e. into i ts two enantiomers by fractional recrystallization of its BOC-L-phenyl alanyl diesters. (C) 1997 Elsevier Science Ltd.