BORON MEDIATED ONE-POT ALDOL-REDUCTION SEQUENCE - ENANTIO AND DIASTEREOSELECTIVE SYNTHESIS OF TYPICAL POLYKETIDE FRAGMENTS

Authors
BONINI C RACIOPPI R RIGHI G ROSSI L
Citation
C. Bonini et al., BORON MEDIATED ONE-POT ALDOL-REDUCTION SEQUENCE - ENANTIO AND DIASTEREOSELECTIVE SYNTHESIS OF TYPICAL POLYKETIDE FRAGMENTS, Tetrahedron : asymmetry, 5(2), 1994, pp. 173-176
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
2
Year of publication
1994
Pages
173 - 176
Database
ISI
SICI code
0957-4166(1994)5:2<173:BMOAS->2.0.ZU;2-X
Abstract
an aldol-reduction one-pot sequence allows syn-syn polyketide fragment s such as 7 to be obtained enantio and diastereoselectively. Enol diis opinocampheylborinate is able to influence both the aldol and the subs equent reduction with NaBH4, via a chelate chair like intermediate.