STUDY OF THE MECHANISM OF THE OPTICAL RESOLUTION OF N-METHYLAMPHETAMINE VIA DIASTEREOISOMERIC SALT FORMATION BY THE POPE-PEACHEY METHOD

Authors
KOZMA D MADARASZ Z ACS M FOGASSY E
Citation
D. Kozma et al., STUDY OF THE MECHANISM OF THE OPTICAL RESOLUTION OF N-METHYLAMPHETAMINE VIA DIASTEREOISOMERIC SALT FORMATION BY THE POPE-PEACHEY METHOD, Tetrahedron : asymmetry, 5(2), 1994, pp. 193-194
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
2
Year of publication
1994
Pages
193 - 194
Database
ISI
SICI code
0957-4166(1994)5:2<193:SOTMOT>2.0.ZU;2-P
Abstract
During the optical resolution of racemic N-methylamphetamine by half a n equivalent of R,R-tartaric acid in the presence of half an equivalen t of hydrochloric acid the tartrate salt of the R-base precipitates wi th a low optical purity. The optical purity of the precipitated salt i s increased by enantiomer exchange between the solid and solvent phase .