IMMUNOGLOBULIN-E AND IMMUNOGLOBULIN-G ANTIBODIES 2 YEARS AFTER A BOOSTER DOSE OF AN ALUMINUM-ADSORBED OR A FLUID DT VACCINE IN RELATION TO ATOPY

Immunoglobulin E and G levels to diphtheria and tetanus toxoids were i nvestigated two years after a DT booster with either an adsorbed or a non-adsorbed, fluid vaccine, given at 10 years of age. Although IgE le vels had declined, detectable IgE to diphtheria and tetanus toxoids we re still found in 82% and 67% of samples, respectively, to be compared to prebooster levels of 3-14% and postbooster levels of 92-94%, The I gG levels had also declined but remained at equal and high levels in b oth the adsorbed and the fluid vaccine groups. The prevalence of aller gic symptoms was similar in the two vaccination groups, Thus, the stud y showed an unexpected, long duration of the ISE responses elicited by a booster dose of DT vaccine. The booster dose also induced a durable , high IgG antibody response to both the adsorbed and the fluid vaccin e.