DESYMMETRIZATION OF MESO-HYDROBENZOIN VIA STEREOSELECTIVE ENZYMATIC ESTERIFICATION

Authors
NICOLOSI G PATTI A PIATTELLI M SANFILIPPO C
Citation
G. Nicolosi et al., DESYMMETRIZATION OF MESO-HYDROBENZOIN VIA STEREOSELECTIVE ENZYMATIC ESTERIFICATION, Tetrahedron : asymmetry, 5(2), 1994, pp. 283-288
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
2
Year of publication
1994
Pages
283 - 288
Database
ISI
SICI code
0957-4166(1994)5:2<283:DOMVSE>2.0.ZU;2-Q
Abstract
Desymmetrization of meso-hydrobenzoin by irreversible acyl transfer us ing vinyl acetate as the acyl donor in the presence of Rhizopus javani cus lipase or Candida cylindracea lipase enables the preparation of (R )-1-acetoxy-(S)-2-hydroxy-1,2-diphenylethane and (S)-1-acetoxy-(R)-2-h ydroxy-1,2-diphenylethane respectively in excellent optical purity.