REGRESSION OF BREAST-CANCER IN 4 PATIENTS TREATED WITH TAMOXIFEN - MAMMOGRAPHIC FEATURES

OBJECTIVE. The purpose of this article is to illustrate the regression of breast cancer as seen on mammograms of women treated with tamoxife n. SUBJECTS AND METHODS. Four elderly patients 72-88 years old were di agnosed with breast cancer on the basis of mammographic features. No s urgery was performed because of multiple medical problems. Tamoxifen w as initiated and the patients were closely monitored with physical exa mination and mammography for a minimum of 2 years. RESULTS, In all cas es, the features of malignancy seen on mammograms regressed. These res ults were documented by a decrease in the number of calcifications and in the size of spiculated masses. CONCLUSION. These results suggest t hat tamoxifen, or one of its metabolites, may alter the biochemical na ture of breast cancer.