A NEW VARIANT OF KNORRS PYRROLE SYNTHESIS

Authors
ZHANG Y JIANG YZ LIANG XT
Citation
Y. Zhang et al., A NEW VARIANT OF KNORRS PYRROLE SYNTHESIS, Chinese journal of chemistry, 15(4), 1997, pp. 371-378
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Chinese journal of chemistry → ACNP
ISSN journal
1001604X
Volume
15
Issue
4
Year of publication
1997
Pages
371 - 378
Database
ISI
SICI code
1001-604X(1997)15:4<371:ANVOKP>2.0.ZU;2-X
Abstract
The reaction between ethyl 3-bromopyruvate and p-substituted anilines was found to involve the unexpected participation of acetone (solvent) forming N-aryl-5-methyl-pyrrole-3-carboxylates. The influence of p-su bstituents of aniline and the feasibility with other ketones were stud ied. N-aryl-indole-3-carboxylate (17) was synthesized successfully wit h this method. The unique character of p-methoxy-aniline in this react ion was discussed.