We describe two patients with renal transplants who developed pseudotu
mor cerebri (PTC) in the course of their follow-up. They illustrate th
e diagnostic challenge in such situation. Patients with renal transpla
nts usually have many other associated conditions which may lead to he
adache, visual disturbances or papilledema, A high index of suspicion
is necessary for prompt diagnosis and management of this rare and seri
ous but treatable combination.