EFFECT OF HIGH-FIBER INTAKE IN FISH OIL-TREATED PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS

The short-term effect of high fiber intake on fish-oil treatment in 15 free-living, non-insulin-dependent diabetic patients was evaluated by using a controlled, sequential study design. During an 8-wk fish-oil- treatment period when patients received 20 g fish oil/d, the usual dai ly fiber intake was increased with a 15-g pectin supplement at midpoin t. Fish oil alone lowered triacylglycerol and very-low-density-lipopro tein-cholesterol concentrations by 41% and 36%, respectively (both P < 0.01 by the end of the treatment period) with unchanged mean total, l ow-density-, and high-density-lipoprotein-cholesterol concentrations. When the fiber intake was increased, however, total and low-density-li poprotein-cholesterol concentrations decreased significantly (P < 0.00 1 and < 0.05, respectively) with fish-oil treatment. The cholesterol e ster fraction of plasma lipids was reduced by 34% when compared with f ish oil alone (P < 0.05). The plasma triacylglycerol fraction decrease d further by 44% (P < 0.001). Other beneficial effects observed includ ed a 30% decline in the fatty acid fraction (P < 0.002) by end of the treatment period. Diabetic control was maintained during the 12-wk stu dy. In conclusion, a high fiber intake may be beneficial in fish oil-t reated diabetic patients.