ANTITHROMBOTIC EFFECTS OF 3-([1 1',2'/1'']-3'-TERPHENYL)PROPANOL IN ANIMALS/

3-([1:1',2':1'']-3'-Terphenyl)propanol (CAS 186835-06-3, F050) and ace ty]salicylic acid (ASA) inhibited platelet aggregation induced by CaCl 2, arachidonic acid, collagen, adenosine diphosphate (ADP) and thrombi n in guinea pigs, rabbits and rats in vitro. However, F050 had a wider spectrum of actions than ASA. Orally administered F050 inhibited plat elet aggregation ex vivo. F050 significantly reduced the thrombus form ation in the extracorporeal circulation thrombosis model in guinea pig s. It inhibited erythrocyte hemolysis induced by hypotonic NaCl, while ASA did not. F050, but not ASA, inhibited Increases in platelet [CA(2 +)]i caused by thrombin in guinea pigs. F050 is a parent compound that will facilitate the development of an orally active drug for the trea tment of thrombotic diseases.