EFFECTS OF A THROMBOXANE A2 RECEPTOR ANTAGONIST IN AN ANIMAL-MODEL OFINFLAMMATORY BOWEL-DISEASE

Background/Aims: We evaluated the effects of an antagonist of the thro mboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bo wel disease (IBD). Methods: Colitis was induced by intracolonic instil lation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ON O-NT-126 or vehicle alone was administered intraluminally via anus onc e a day. The rats were killed after 7 days for assessment of colonic d amage by the colonic damage score. Results and Conclusion: ONO-NT-126 markedly reduced the colonic damage. Our findings suggest that the thr omboxane-thromboxane receptor system plays an important role in this m odel of IBD and that antagonism of the thromboxane A2 receptor may pro ve useful for the treatment of IBD.