ENDOTHELIN-1 IN MECHANISMS OF NEPHROTOXIC ACTION OF RADIOPAQUE MEDIA

The authors study mechanisms of nephrotoxic action of high osmolar rad iopaque substance (RPS) and the role of endothelin-1, hormonal endothe lial factor, in these mechanisms in patients with different variants o f chronic glomerulonephritis. Endothelin-1 is a potent endogenic vasoc onstrictor participating in regulation of intrarenal hemodynamics and renal function the synthesis of which is related to Ca metabolism. Mec hanisms of nephrotoxic action of RPS involve disturbances of Ca metabo lism (hypercalciemia), high concentration of blood endothelin-1 which directly correlated with baseline creatinine in the serum and deterior ation of renal function after RPS introduction. Ca ions antagonists (c orinfar) contribute to prevention of changes in endothelin-1 synthesis and relevant renal dysfunction induced by RPS.