COMPARATIVE INVESTIGATION OF ANTICLASTOGENIC EFFECTS IN CELL-CULTURESOF HEALTHY DONORS AND PATIENTS WITH NETTLE-RASH

In cultures of lymphocytes from 12 healthy donors and 12 patients with nettle-rash (NR) the anticlastogenic effect of the antimutagens WR-27 21 (WR), bemitil (BM), tomerzol (TM) and interferon (IF) on the induct ion of chromosomal aberrations by photrin (PT) and dioxidine (DX) was investigated. There were no statistically significant differences betw een healthy donors and patients with NR in the levels of chromosomal a berrations that were spontaneous or induced by PT or DX. Statistically significant protective effects of BM, WR, TM and IF were demonstrated in cells of healthy donors after treatment with PT or DX, and after m odification of the clastogenic action of PT in lymphocytes of NR patie nts. There was no protective effect of any of the anticlastogens after treatment of the lymphocyte cultures from NR patients with DX. That o bservation allows us to suggest the test of anticlastogenic action as a measure of sensitivity of the chromosomal apparatus in groups with d ifferent genetic risks.