CHANGES IN THE INTENSITY OF CELL-PROLIFER ATION AND SPONTANEOUS DEATHIN THE PRIMARY TUMOR - AND METASTASES IN MICE WITH LEWIS CARCINOMA - THE INFLUENCE OF THE PRIMARY TUMOR SURGERY

Changes in proliferation and spontaneous death of the tumor death have been studied during the Lewis carcinoma growth and dissemination afte r the primary tumour surgery. The slowed down rate of the primary tumo ur growth was shown to be due to spontaneous death of cells. Lung meta stases are characterized by a high proliferative activity of tumour ce lls and a low cell loss. The primary tumour surgery stimulates lung me tastases via enhanced proliferation of the tumour cells with apoptosis preserved at the same level.