NON-HODGKIN-LYMPHOMA (NHL) AS A 2ND NEOPLASM OCCURRING AFTER NEUROBLASTOMA TREATMENT

As far as we know, this is the first report of a non-Hodgkin lymphoma developing after successful treatment of neuroblastoma. A boy was foun d to have a mediastinal T-cell lymphoma at the age of 5. He had been t reated for a neuroblastoma of the left adrenal region 4 years before, when by intensive chemotherapy and radiation a complete remission of t he primary tumor was achieved. The second malignancy has also been con trolled without evidence of recurrence 1 year after termination of tre atment. We conclude that treatment of a neuroblastoma by cytostatic dr ugs and radiation may lead to a non-Hodgkin lymphoma as a second malig nancy. (C) 1998 Wiley-Liss, Inc.